Pediatric Diabetes

 Insulin resistance is higher in prepubertal girls but switches to become higher in boys at age 16: A Cohort Study (EarlyBird 57)
Background The risk of type 2 diabetes is increasing in teenage girls, and is associated with their greater insulin resistance (IR). Hypothesis We hypothesized that the adverse metabolic profile of girls (compared with boys) would persist from childhood through adolescence. Patients and Methods Community-based longitudinal cohort of 292 children (147 boys) studied annually from 9 to 16?years. Measures: IR (homeostasis-model-assessment-2), high-density lipoprotein-cholesterol (HDL-C), triglycerides, % body-fat (dual-energy x-ray absorptiometry), pubertal stage (age at peak height velocity), physical activity (accelerometry). Multi-level modelling established the age-related trends in IR and lipids and the influence of covariates. Results Each year from 9 to 15?years, girls had 21% to 63% higher IR than boys (girls mean IR 0.73-1.33, boys 0.51-0.89, P??.07). However, after adjustment at 16?years, girls? IR was 25% lower than boys? (girls 0.44, boys 0.63, P?=?.001), and they had 22% higher HDL-C (P?