Pediatric Diabetes

 Improvements in peripheral vascular function with vitamin D treatment in deficient adolescents with type 1 diabetes
Background Vitamin D (VitD) deficiency is prevalent in adolescents with type 1 diabetes (T1D) and is associated with diabetes-related vascular complications in adulthood. The objective of this clinical trial was to assess VitD treatment on endothelial function (EF) and markers of renal inflammation, in this patient group. Methods Adolescents with T1D with suboptimal levels of VitD (<37.5?nmol/L) were treated for 12 to 24 weeks with a VitD analog (VitD3) at doses of 1000 or 2000?IU daily. The primary end-point assessed the change in reactive hyperemia index (lnRHI), a measure of EF. Secondary end-points included changes in blood pressure, lipid profile, HbA1c and albumin creatinine ratio (ACR). Urinary cytokine/chemokine inflammatory profile was also assessed in a subset of subjects posttreatment. Results Two hundred and seventy-one subjects were screened for VitD status and 31 VitD deficient subjects with a mean age of 15.7?±?1.4?years were enrolled and completed the study. Mean 25-OH-VitD levels significantly increased (33.0?±?12.8 vs 67.0?±?23.2?nmol/L, P?