Clinical Endocrinology & Metabolism

 Daily rhythms count for female fertility
Female ovulation depends on a surge in circulating luteinizing hormone (LH) which occurs at the end of the resting period and requests high circulating estradiol. This fine tuning involves both an estradiol feedback as an indicator of oocyte maturation, and the master circadian clock of the suprachiasmatic nuclei as an indicator of the time of the day. This review describes the mechanisms through which daily time cues are conveyed to reproductive hypothalamic neurons to time the pre-ovulatory surge.